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Transport molecule forms a protective structure to guide proteins to cell membrane

Transport molecule forms a protective structure to guide proteins to cell membrane

March 5, 2015 The molecular complex that guides an important class of proteins to correct locations in cell membranes does so by forming a dimeric structure with a protective pocket, report scientists from the University of Chicago in Science on Mar. 5.

Epigenetic "switch" regulates RNA-protein interactions

Epigenetic "switch" regulates RNA-protein interactions

February 25, 2015 Chemical changes – also known as epigenetic modifications – to messenger RNA (mRNA) are thought to play an important role in gene expression, and have recently been found to affect biological processes such as circadian clock management and obesity. But the specific mechanisms involved have been poorly understood.

New study helps explain links between sleep loss and diabetes

New study helps explain links between sleep loss and diabetes

February 19, 2015 Lack of sleep can elevate levels of free fatty acids in the blood, accompanied by temporary pre-diabetic conditions in healthy young men, according to new research published online February 19, 2015, in Diabetologia , the journal of the European Association for the Study of Diabetes. The study, the first to examine the impact of sleep loss on 24-hour fatty acid levels in the blood, adds to emerging evidence that insufficient sleep — a highly prevalent condition in modern society — may disrupt fat metabolism and reduce the ability of insulin to regulate blood sugars.

Comer Children’s Hospital Celebrates 10th Anniversary

Comer Children’s Hospital Celebrates 10th Anniversary

February 17, 2015 The Comer Children’s Hospital at the University of Chicago Medicine is marking its first decade of outstanding contributions in the care of children from the Chicago area and elsewhere in the United States and around the world. When it first opened its doors on Feb.

Seasonal flu vaccine induces antibodies that protect against H7N9 avian flu

Seasonal flu vaccine induces antibodies that protect against H7N9 avian flu

February 17, 2015 Antibodies that protect against H7N9 avian flu, which emerged in China in 2013 and sparked fears of a global pandemic, have been isolated in individuals who received seasonal flu vaccinations. These antibodies account for a small percentage of the total immune response, but appear to broadly neutralize H7 viruses and represent promising new targets for therapeutic development against a wide range of influenza strains, report scientists from the University of Chicago and Icahn School of Medicine at Mount Sinai in the Journal of Clinical Investigation on Feb 17.

Earliest-known arboreal and subterranean ancestral mammals discovered

Earliest-known arboreal and subterranean ancestral mammals discovered

February 12, 2015 The fossils of two interrelated ancestral mammals, newly discovered in China, suggest that the wide-ranging ecological diversity of modern mammals had a precedent more than 160 million years ago. With claws for climbing and teeth adapted for a tree sap diet, Agilodocodon scansorius is the earliest-known tree-dwelling mammaliaform (long-extinct relatives of modern mammals).

New screening tool could speed development of ovarian cancer drugs

New screening tool could speed development of ovarian cancer drugs

February 10, 2015 University of Chicago Medicine researchers have built a model system that uses multiple cell types from patients to rapidly test compounds that could block the early steps in ovarian cancer metastasis. Their three-dimensional cell-culture system, adapted for high-throughput screening, has enabled them to identify small molecules that can inhibit adhesion and invasion, preventing ovarian cancers from spreading to nearby tissues.

MicroRNAs can limit cancer spread

MicroRNAs can limit cancer spread

February 3, 2015 Cancers that have spread throughout the body, a process known as metastasis, are difficult, often impossible, to control. They are the leading cause of cancer-related deaths.

University of Chicago Medicine opens Heart and Vascular Center

University of Chicago Medicine opens Heart and Vascular Center

February 2, 2015 The University of Chicago Medicine has launched the Heart and Vascular Center, which combines resources from three clinical specialties to meet the growing needs of patients seeking cardiovascular care in a highly coordinated setting. This new center, which includes more than 40 faculty physicians, incorporates specialists, technologies and dedicated nursing and support staff into a carefully orchestrated network of world-renowned experts focused on medical problems involving the heart and blood vessels.

Ancient "genomic parasites" spurred evolution of pregnancy in mammals

Ancient "genomic parasites" spurred evolution of pregnancy in mammals

January 29, 2015 An international team of scientists has identified large-scale genetic changes that marked the evolution of pregnancy in mammals. They found thousands of genes that evolved to be expressed in the uterus in early mammals, including many that are important for maternal-fetal communication and suppression of the immune system.

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