List/Grid Tag Archives: tumors

–Phase II study shows meaningful reduction in brain tumor size in 75% of patients with subependymal giant cell astrocytomas (SEGAs) from baseline to six months (1) –SEGAs are benign brain tumors associated with tuberous sclerosis (TS) that primarily affect children and adolescents and can cause severe brain swelling (2) –No patient developed new tumors or needed brain surgery, the only current treatment option for patients with SEGAs that are growing (1) –Novartis submitted file to FDA based on this study of 28 patients and is enrolling the EXIST Phase III trials to further study everolimus in patients with TS EAST HANOVER, N.J., June 5 /CHICAGOPRESSRELEASE.COM/ — Novartis Pharmaceuticals Corporation (“Novartis”) announced today that results from a Phase II study show Afinitor® (everolimus) tablets is the first medication in a clinical trial to decrease the size of subependymal giant cell astrocytomas (SEGAs), benign brain tumors associated with tuberous sclerosis (TS) (1,2). In this study of 28 patients presented today at the 46th American Society of Clinical Oncology (ASCO) annual meeting in Chicago, 75% of patients experienced a reduction of 30% or greater in the size of their brain tumors from baseline to six months (p